Changing architecture: A new understanding of the spatial organization

(Max Delbrück Center for Molecular Medicine in the Helmholtz Association) Fifteen years ago, scientists had determined the entire sequence of the genetic letters making up our DNA. But this was only a step in a long journey: in addition to the letters, information is also encoded in the packing of DNA. A team led by Ana Pombo from the Max Delbrück Center in Berlin has now generated comprehensive 3-D maps of the spatial organization of the mouse genome. Such maps might help track down genes inv...